Sugi Predict

Sugi Predict / Compounds / SCHEMBL759

SCHEMBL759

SCHEMBL759

ClCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SIRT2 Q8IXJ6 15/20 0.45
▸ CYP11B1 P15538 1/20 0.43
▸ CYP11B2 P19099 1/20 0.43
▸ ENPP2 Q13822 1/20 0.39
▸ MEN1 O00255 1/20 0.36
▸ SLC22A1 O15245 1/20 0.36
▸ KCNN4 O15554 1/20 0.36
▸ NR1I2 O75469 1/20 0.36
▸ GMNN O75496 1/20 0.36
▸ USP2 O75604 1/20 0.36
▸ TRPM2 O94759 1/20 0.36
▸ ABCB11 O95342 1/20 0.36
▸ EGFR P00533 1/20 0.36
▸ CA2 P00918 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ NR3C1 P04150 1/20 0.36
▸ ERBB2 P04626 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ CYP17A1 P05093 1/20 0.36
▸ CYP1A2 P05177 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6926362 0.98 SIRT2 (0.44) SIRT2CYP11B1CYP11B2ENPP2MEN1
SCHEMBL7159342 0.87 SIRT2 (0.49) SIRT2CYP11B1CYP11B2ENPP2MEN1
SCHEMBL2490264 0.85 SIRT2 (0.48) SIRT2CYP11B1CYP11B2ENPP2MEN1
Hydrochloric Acid SCHEMBL9531432 0.85 SIRT2 (0.48) SIRT2CYP11B1CYP11B2ENPP2MEN1
Hydrochloric Acid SCHEMBL7988290 0.84 SIRT2 (0.47) SIRT2CYP11B1CYP11B2ENPP2MEN1
SCHEMBL8165853 0.84 SIRT2 (0.47) SIRT2CYP11B1CYP11B2ENPP2MEN1
SCHEMBL1924923 0.83 SIRT2 (0.45) SIRT2CYP11B1CYP11B2ENPP2MAOA
SCHEMBL2038903 0.83 SIRT2 (0.45) SIRT2CYP11B1CYP11B2ENPP2MEN1
SCHEMBL6355465 0.83 SIRT2 (0.45) SIRT2CYP11B1CYP11B2ENPP2MEN1
SCHEMBL7269738 0.83 SIRT2 (0.50) SIRT2CYP11B1CYP11B2ENPP2NMBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0599697-A1 Pyrrole derivatives, their preparation and application in therapy SYNTHELABO (FR) 1994-06-01 — — EP claimed
US-20250296915-A1 NOVEL AMINO ACID DERIVATIVES PEPTIDREAM INC (JP) 2025-09-25 — — US disclosed
US-20240400499-A1 NOVEL AMINO ACID DERIVATIVES PEPTIDREAM INC (JP) 2024-12-05 — — US disclosed
CN-118684633-A Androgen receptor modulators and methods of use thereof 埃萨制药股份有限公司 2024-09-24 — — CN disclosed
CN-113195441-B Androgen receptor modulators and methods of use thereof 埃萨制药股份有限公司 2024-07-12 — — CN disclosed
US-20220380325-A1 ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE PROVINCIAL HEALTH SERVICES AUTHORITY (CA) 2022-12-01 — — US disclosed
US-11339144-B2 Heteroaryl Rheb inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2022-05-24 — — US disclosed
US-11339144-B2 Heteroaryl Rheb inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2022-05-24 — — US disclosed
US-20210238165-A1 HETEROARYL RHEB INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2021-08-05 — — US disclosed
US-20210238165-A1 HETEROARYL RHEB INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2021-08-05 — — US disclosed
US-5091425-A Inhibitors of the catalytic action of renin IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-02-25 — — US disclosed
EP-0369743-A2 Heterocyclic amides ZENECA LIMITED (GB) 1990-05-23 — — EP disclosed
EP-0194984-B1 DERIVATIVES OF IMIDAZOLE, THEIR PREPARATION AND UTILISATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES CONTINENTAL PHARMA, INC. (BE) 1990-04-04 — — EP disclosed
US-4882343-A ADRENERGIC BLOCKING AGENTS G. D. SEARLE & CO. (US) 1989-11-21 — — US disclosed
US-4859662-A Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances GLAXO GROUP LIMITED (GB) 1989-08-22 — — US disclosed
US-4822881-A PSYCHOTIC DISORDERS, ANXIETY, NAUSEA, VOMITING GLAXO GROUP LIMITED 1989-04-18 — — US disclosed
EP-0306323-A2 Lactam derivatives GLAXO GROUP LIMITED (GB) 1989-03-08 — — EP disclosed
EP-0304910-A1 Biarylalkylimidazole derivatives as antidepressants G.D. Searle & Co. (US) 1989-03-01 — — EP disclosed
US-4738979-A ADRENERGIC RECEPTORS; ANTI-CONVULSIVE DRUG; TREATMENT OF METABOLIC AND NEUTRAL DISORDERS G. D. SEARLE & CO. (US) 1988-04-19 — — US disclosed
EP-0194984-A1 Derivatives of imidazole, their preparation and utilisation, and pharmaceutical compositions containing these derivatives CONTINENTAL PHARMA, INC. (BE) 1986-09-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238165-A1 HETEROARYL RHEB INHIBITORS AND USES THEREOF RHEB, KRAS, NRAS SIRT2 2241/4885CYP11B1 223/4885CYP11B2 277/4885
US-20250296915-A1 NOVEL AMINO ACID DERIVATIVES DNPEP, BCAT1, ANPEP SIRT2 3857/4885CYP11B1 4734/4885CYP11B2 4650/4885
US-11339144-B2 Heteroaryl Rheb inhibitors and uses thereof RHEB, GDI2, KRAS SIRT2 3157/4885CYP11B1 130/4885CYP11B2 202/4885
US-20220380325-A1 ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE AR, NR5A1, CYP17A1 SIRT2 3295/4885CYP11B1 9/4885CYP11B2 11/4885
US-20240400499-A1 NOVEL AMINO ACID DERIVATIVES BCAT1, BCAT2, PELP1 SIRT2 3205/4885CYP11B1 4665/4885CYP11B2 4550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.