Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000906 | 0.90 | CYP1A2 (0.37) | TP53CYP1A2CYP2A6DPP4HTT | |
| SCHEMBL5264237 | 0.82 | CYP1A2 (0.41) | TP53CYP1A2CYP2A6DPP4HTT | |
| SCHEMBL7127029 | 0.81 | TP53 (0.36) | TP53CYP1A2CYP2A6DPP4HTT | |
| SCHEMBL7126396 | 0.78 | CYP1A2 (0.36) | TP53CYP1A2CYP2A6DPP4HTT | |
| SCHEMBL7119512 | 0.75 | KDM1A (0.39) | TP53CYP1A2CYP2A6HTTSMN1; SMN2 | |
| SCHEMBL7131287 | 0.74 | KDM4E (0.40) | TP53CYP1A2CYP2A6DPP4HTT | |
| SCHEMBL2127858 | 0.74 | CYP1A2 (0.39) | TP53CYP1A2CYP2A6DPP4HTT | |
| SCHEMBL3926851 | 0.73 | DPP4 (0.36) | CYP1A2CYP2A6DPP4HTTSMN1; SMN2 | |
| SCHEMBL9000819 | 0.72 | KDM4E (0.36) | TP53CYP1A2CYP2A6HTTSMN1; SMN2 | |
| SCHEMBL9000584 | 0.72 | PTGS1 (0.34) | PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628064-B2 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2003-12-10 | — | — | EP | claimed |
| EP-0628064-B1 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 1999-04-07 | — | — | EP | claimed |
| EP-0628064-A4 | PHOTOCHROMIC NAPHTHOPYRANS. | PPG INDUSTRIES INC (US) | 1995-02-08 | — | — | EP | claimed |
| EP-0628064-A1 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1994-12-14 | — | — | EP | claimed |
| WO-1993017071-A1 | PHOTOCHROMIC NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1993-09-02 | — | — | WO | claimed |
| US-5238981-A | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1993-08-24 | — | — | US | claimed |