Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 3/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264237 | 0.90 | CYP1A2 (0.41) | TP53CYP1A2CYP2A6SMN1; SMN2KDM4E | |
| SCHEMBL5615504 | 0.89 | AHR (0.38) | TP53ACP1AHRCYP1A2SMN1; SMN2 | |
| SCHEMBL2134543 | 0.87 | CYP11B1 (0.41) | CYP1A2CYP2A6SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7126396 | 0.87 | CYP1A2 (0.36) | TP53MAOBCYP1A2CYP2A6SMN1; SMN2 | |
| SCHEMBL7723531 | 0.86 | CYP11B1 (0.41) | CYP1A2CYP2A6SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7119512 | 0.84 | KDM1A (0.39) | TP53MAOBCYP1A2CYP2A6SMN1; SMN2 | |
| SCHEMBL5615529 | 0.84 | ALDH1A1 (0.42) | CYP1A2SMN1; SMN2KDM4ENPC1HPGD | |
| SCHEMBL7131287 | 0.82 | KDM4E (0.40) | TP53CYP1A2CYP2A6SMN1; SMN2KDM4E | |
| SCHEMBL5615321 | 0.81 | SMN1; SMN2 (0.43) | CYP1A2CYP2A6SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7160609 | 0.81 | TP53 (0.40) | TP53CYP1A2CYP2A6SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628064-B2 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-0628064-B1 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5585042-A | REVERSIBLE CHANGE IN COLOR WHEN EXPOSURED TO ULTRAVIOLET RADIATION | TRANSITIONS OPTICAL, INC. (US) | 1996-12-17 | — | — | US | disclosed |
| EP-0628064-A4 | PHOTOCHROMIC NAPHTHOPYRANS. | PPG INDUSTRIES INC (US) | 1995-02-08 | — | — | EP | disclosed |
| EP-0628064-A1 | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1994-12-14 | — | — | EP | disclosed |
| US-5369158-A | And polymer | TRANSITIONS OPTICAL, INC. (US) | 1994-11-29 | — | — | US | disclosed |
| WO-1993017071-A1 | PHOTOCHROMIC NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1993-09-02 | — | — | WO | disclosed |
| US-5238981-A | PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 1993-08-24 | — | — | US | disclosed |