Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.31 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417855 | 0.80 | ALDH1A1 (0.43) | — | |
| Valine SCHEMBL7133166 | 0.79 | SLC7A5 (0.60) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| SCHEMBL1345757 | 0.78 | ALDH1A1 (0.41) | — | |
| Valine SCHEMBL10995178 | 0.75 | SLC7A5 (0.65) | SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Valine SCHEMBL1535415 | 0.72 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Valine SCHEMBL25206795 | 0.72 | SLC7A5 (0.60) | SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Valine SCHEMBL28429527 | 0.72 | SLC7A5 (0.60) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Valine SCHEMBL22187050 | 0.72 | SLC7A5 (0.60) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Valine SCHEMBL11516641 | 0.70 | SLC7A5 (0.71) | SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Valine SCHEMBL3733606 | 0.70 | SLC7A5 (0.71) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506929-B1 | Selectively reducing carbonyl function of lactone moiety of lovastatin to hemiacetal, methylating with strong base and methyl iodide in inert solvent, oxidizing product to give simvastatin | APOTEX INC. (CA) | 2003-01-14 | — | — | US | disclosed |
| EP-1087958-B1 | PROCESS TO MANUFACTURE SIMVASTATIN AND INTERMEDIATES | APOTEX INC (CA) | 2002-09-04 | — | — | EP | disclosed |
| EP-1087958-A1 | PROCESS TO MANUFACTURE SIMVASTATIN AND INTERMEDIATES | APOTEX INC. (CA) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065892-A1 | PROCESS TO MANUFACTURE SIMVASTATIN AND INTERMEDIATES | APOTEX INC. (CA) | 1999-12-23 | — | — | WO | disclosed |