Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GALR2 | O43603 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7157761 | 0.87 | RAB9A (0.60) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL7161447 | 0.84 | NPC1 (0.60) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL7163839 | 0.84 | NPC1 (0.62) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL7161524 | 0.82 | RAB9A (0.61) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL7848327 | 0.81 | RAB9A (0.69) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6815762 | 0.79 | MEN1 (0.50) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6816416 | 0.78 | MAPT (0.51) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6815215 | 0.78 | KDM4E (0.51) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6815229 | 0.77 | SMN1; SMN2 (0.47) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL7159272 | 0.77 | RAB9A (0.62) | NPC1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555561-B2 | N-(5-((((5-Chloro-2,4-dimethoxyphenyl)amino)thioxomethyl)-amino)-2 -pyridinyl)-2-methylbenzamide, for example; inhibiting replication of a herpes virus | WYETH | 2003-04-29 | — | — | US | disclosed |