Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL7163058 | 1.00 | AKR1C3 (0.55) | AKR1C3TBXAS1TRPA1ABCB11SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7565316 | 0.91 | AKR1C3 (0.64) | AKR1C3TBXAS1TRPA1ABCB11SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7565312 | 0.91 | AKR1C3 (0.64) | AKR1C3TBXAS1TRPA1ABCB11SIGMAR1 | |
| SCHEMBL1972603 | 0.89 | AKR1C3 (0.67) | AKR1C3TBXAS1TRPA1ABCB11SIGMAR1 | |
| SCHEMBL12181893 | 0.89 | AKR1C3 (0.67) | AKR1C3TBXAS1TRPA1ABCB11SIGMAR1 | |
| SCHEMBL2585302 | 0.89 | AKR1C3 (0.67) | AKR1C3TBXAS1TRPA1ABCB11SIGMAR1 | |
| SCHEMBL1842887 | 0.84 | AKR1C3 (0.60) | AKR1C3TRPA1ABCB11SIGMAR1FBP1 | |
| Guanidine SCHEMBL7158194 | 0.83 | AKR1C3 (0.46) | AKR1C3TBXAS1FBP1PTGS2 | |
| Guanidine SCHEMBL7158197 | 0.83 | AKR1C3 (0.46) | AKR1C3TBXAS1FBP1PTGS2 | |
| SCHEMBL3860890 | 0.83 | AKR1C3 (0.58) | AKR1C3TBXAS1TRPA1ABCB11SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6504057-B2 | Anti-arrhythmia, -ischemic, -proliferative and -diabetic agents; cardiotonic, necrosis; angina pectoris; peripheral and central nervous systems; protecting/preserving organs; inhibition of Na+/H+ exchange; diagnosis hypertonia | HOECHST AKTIENGESELLSCHAFT (DE) | 2003-01-07 | — | — | US | disclosed |
| US-20010020042-A1 | Cardiovascular disorders | HOECHST AKTIENGESELLSCHAFT | 2001-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020042-A1 | Cardiovascular disorders | SLC5A1, SLC9A1, SLC28A1 | AKR1C3 393/4885TBXAS1 1700/4885TRPA1 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.