Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.53 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GGT1 | P19440 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667165 | 0.87 | KDM4E (0.79) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL1708883 | 0.81 | MMP2 (0.55) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL16719162 | 0.81 | KDM4E (0.71) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL31226473 | 0.81 | MMP2 (0.55) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL6264392 | 0.81 | KDM4E (0.71) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL7167064 | 0.81 | MMP2 (0.47) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL8676658 | 0.80 | KDM4E (0.69) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL1315833 | 0.80 | KDM4E (1.00) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| Dipyrocetyl SCHEMBL29508594 | 0.80 | MAPK1 (1.00) | HSD17B10KDM4EALDH1A1HPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL29744423 | 0.80 | MMP2 (0.53) | HSD17B10KDM4EALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218368-A4 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | HUTCHINSON FRED CANCER RES (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-1218368-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | Fred Hutchinson Cancer Research Center (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001014365-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2001-03-01 | — | — | WO | disclosed |
| CN-1036582-A | The preparation method of polypeptide derivative | OTSUKA CHEMICAL CO LTD (JP) | 1989-10-25 | — | — | CN | disclosed |