Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP7 | P55210 | 12/20 | 0.41 |
| ▸ | CASP3 | P42574 | 11/20 | 0.41 |
| ▸ | CASP1 | P29466 | 5/20 | 0.41 |
| ▸ | CASP6 | P55212 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409498 | 0.82 | ECE1 (0.33) | — | |
| SCHEMBL7139606 | 0.82 | ECE1 (0.33) | — | |
| SCHEMBL5401352 | 0.69 | ECE1 (0.32) | — | |
| SCHEMBL5407110 | 0.67 | ECE1 (0.36) | CYP2D6DPP4DPP8DPP9DPP7 | |
| SCHEMBL4601664 | 0.66 | CASP3 (0.45) | CASP7CASP3CASP1CASP6 | |
| SCHEMBL13986079 | 0.65 | S1PR1 (0.45) | CASP7CASP3FKBP1A | |
| SCHEMBL13986075 | 0.65 | S1PR1 (0.45) | CASP7CASP3FKBP1A | |
| SCHEMBL13097237 | 0.65 | CYP1A2 (0.35) | CASP7CASP3CASP1CASP6 | |
| SCHEMBL13986071 | 0.65 | S1PR1 (0.45) | CASP7CASP3FKBP1A | |
| SCHEMBL13986070 | 0.65 | S1PR1 (0.45) | CASP7CASP3FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303486-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | claimed |
| WO-2002008185-A1 | PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-31 | — | — | WO | claimed |