Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 6/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353781 | 1.00 | CA1 (0.51) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL19227630 | 0.89 | CA1 (0.58) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL28421522 | 0.87 | CA1 (0.50) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL5262474 | 0.84 | CA1 (0.53) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL4032796 | 0.84 | CA1 (0.53) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL8560322 | 0.84 | CA1 (0.53) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL15250454 | 0.84 | CA1 (0.53) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL8561571 | 0.84 | CA1 (0.53) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL21169229 | 0.84 | CA1 (0.53) | CA1CA2CA7CTSKCTSL | |
| SCHEMBL272780 | 0.84 | CA1 (0.53) | CA1CA2CA7CTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751774-B1 | HYPOCHOLESTEROLEMIC MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES | MERRELL PHARMA INC (US) | 2003-08-13 | — | — | EP | disclosed |
| EP-0745081-B1 | INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMA INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0750631-B1 | NOVEL MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO(C)AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMA INC (US) | 2000-04-05 | — | — | EP | disclosed |
| US-6013645-A | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives | HOECHST MARION ROUSSEL, INC. (US) | 2000-01-11 | — | — | US | disclosed |
| US-5880119-A | Mercaptoacetylamino 1,3,4,5-tetrahydro-benzo(C)azepin-2-one disulfide derivatives useful as inhibitors of enkephalinase and ACE | MERRELL PHARMACEUTICALS INC. (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0745080-B1 | NOVEL MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5750521-A | Mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE | HOECHST MARION ROUSSEL INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5731306-A | Mercaptoacetylamido 1,3,4,5-tetrahydro-benzo c!azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace | AVENTISUB II INC. | 1998-03-24 | — | — | US | disclosed |
| US-5629309-A | 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE | MERRELL PHARMACEUTICALS INC. (US) | 1997-05-13 | — | — | US | disclosed |
| US-5604221-A | Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase | MERRELL PHARMACEUTICALS INC. (US) | 1997-02-18 | — | — | US | disclosed |
| EP-0750631-A1 | NOVEL MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO(C)AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-02 | — | — | EP | disclosed |
| EP-0746566-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0745081-A1 | NOVEL INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| EP-0745080-A1 | NOVEL MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| US-5567814-A | 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ACE | MERRELL PHARMACEUTICALS INC. (US) | 1996-10-22 | — | — | US | disclosed |
| WO-1995025519-A1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1995-09-28 | — | — | WO | disclosed |
| WO-1995021857-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021839-A1 | NOVEL MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021854-A1 | NOVEL MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021840-A1 | NOVEL INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |