Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8493103 | 0.93 | CTSL (0.56) | CTSLGAAMAPTL3MBTL1 | |
| SCHEMBL8096343 | 0.91 | GAA (0.53) | CTSLGAAMAPTL3MBTL1HPGD | |
| SCHEMBL8096338 | 0.91 | GAA (0.53) | CTSLGAAMAPTL3MBTL1HPGD | |
| SCHEMBL7165303 | 0.83 | HPGD (0.45) | GAAMAPTL3MBTL1HPGD | |
| SCHEMBL8321465 | 0.83 | CTSL (0.48) | CTSLGAAMAPTL3MBTL1 | |
| SCHEMBL8321467 | 0.83 | CTSL (0.48) | CTSLGAAMAPTL3MBTL1 | |
| SCHEMBL941477 | 0.83 | CTSL (0.66) | CTSLGAAMAPTL3MBTL1 | |
| SCHEMBL941478 | 0.83 | CTSL (0.66) | CTSLGAAMAPTL3MBTL1 | |
| SCHEMBL7162881 | 0.82 | CTSL (0.61) | CTSLGAAMAPTL3MBTL1 | |
| SCHEMBL7162877 | 0.82 | CTSL (0.61) | CTSLGAAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566375-B1 | For therapy of atherosclerosis | WYETH | 2003-05-20 | — | — | US | claimed |
| US-6316467-B1 | Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-13 | — | — | US | claimed |
| WO-1999025682-A1 | ELEVATION OF HDL CHOLESTEROL BY 4-[(AMINOTHIOXOMETHYL) -HYDRAZONO] -N-(SUBSTITUTED) -4-ARYLBUTANAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-05-27 | — | — | WO | claimed |
| US-6566375-B1 | For therapy of atherosclerosis | WYETH | 2003-05-20 | — | — | US | disclosed |
| US-6316467-B1 | Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-13 | — | — | US | disclosed |
| WO-1999025682-A1 | ELEVATION OF HDL CHOLESTEROL BY 4-[(AMINOTHIOXOMETHYL) -HYDRAZONO] -N-(SUBSTITUTED) -4-ARYLBUTANAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-05-27 | — | — | WO | disclosed |