Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 15/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 15/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 15/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 15/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 15/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 15/20 | 0.46 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.41 |
| ▸ | NOTCH3 | Q9UM47 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168726 | 0.87 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7185882 | 0.84 | NOTCH1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7165023 | 0.84 | NOTCH1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7193604 | 0.83 | CCKBR (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7164600 | 0.81 | NOTCH1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7168972 | 0.81 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6004975 | 0.81 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6005868 | 0.81 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7170270 | 0.80 | PSEN1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7168082 | 0.80 | NOTCH1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |