Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 12/20 | 0.38 |
| ▸ | NPY1R | P25929 | 7/20 | 0.38 |
| ▸ | NPY2R | P49146 | 5/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.38 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HPN | P05981 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168920 | 0.87 | NPY4R (0.35) | NPY4RNPY1RNPY2RNPY5R | |
| SCHEMBL7170368 | 0.84 | NPY4R (0.42) | NPY4RNPY1RNPY2RNPY5RPLAU | |
| SCHEMBL7167389 | 0.82 | AVPR1B (0.35) | NPY4RNPY1RNPY2RNPY5R | |
| Hydrochloric Acid SCHEMBL11142424 | 0.81 | PLAU (0.39) | NPY4RNPY1RNPY2RNPY5RPLAU | |
| SCHEMBL8818610 | 0.79 | ITGB3 (0.41) | NPY4RNPY1RNPY2RNPY5RPLAU | |
| SCHEMBL7168204 | 0.76 | PLG (0.34) | NPY4RNPY1RPLAU | |
| SCHEMBL7171608 | 0.76 | PLG (0.34) | NPY4RNPY1RPLAU | |
| SCHEMBL7170068 | 0.76 | NPY4R (0.35) | NPY4RNPY1RNPY2RNPY5R | |
| Hydrochloric Acid SCHEMBL11142106 | 0.73 | LARS1 (0.40) | NPY4RNPY1RNPY2RNPY5RMMP2 | |
| SCHEMBL8817382 | 0.72 | ITGB3 (0.41) | NPY4RNPY1RNPY2RNPY5RPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789578-B1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0789578-A4 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-0789578-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1996014857-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1996-05-23 | — | — | WO | disclosed |