Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 20/20 | 0.51 |
| ▸ | FNTB | P49356 | 16/20 | 0.51 |
| ▸ | PGGT1B | P53609 | 16/20 | 0.51 |
| ▸ | NRAS | P01111 | 1/20 | 0.50 |
| ▸ | HRAS | P01112 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7163417 | 0.82 | FNTA (0.45) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7164727 | 0.82 | FNTA (0.48) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7718965 | 0.81 | FNTA (0.66) | FNTAFNTBPGGT1B | |
| SCHEMBL7718963 | 0.81 | FNTA (0.66) | FNTAFNTBPGGT1B | |
| SCHEMBL7532831 | 0.80 | FNTA (0.78) | FNTAFNTBPGGT1BNRASHRAS | |
| Hydrochloric Acid SCHEMBL7653563 | 0.79 | FNTA (0.77) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL6434433 | 0.79 | FNTA (0.45) | FNTAFNTBPGGT1BNRASHRAS | |
| Trifluoroacetic Acid SCHEMBL7166202 | 0.79 | FNTA (0.52) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL6471063 | 0.78 | FNTA (0.53) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7163856 | 0.77 | FNTA (0.48) | FNTAFNTBPGGT1BNRASHRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| WO-2000016778-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 2000-03-30 | — | — | WO | disclosed |