Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.60 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.60 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7160571 | 0.92 | MAPT (0.55) | MAPTMAPK1GAAKCNK3KCNK9 | |
| SCHEMBL7160516 | 0.92 | KCNK3 (0.65) | MAPTMAPK1GAAKCNK3KCNK9 | |
| Ethenzamide SCHEMBL25624 | 0.83 | MAPT (0.68) | MAPTMAPK1GAAHCRTR1MEN1 | |
| Ethenzamide SCHEMBL27612766 | 0.83 | MAPT (0.68) | MAPTMAPK1GAAHCRTR1MEN1 | |
| SCHEMBL7167278 | 0.82 | MAPT (0.53) | MAPTMAPK1GAAKCNK3KCNK9 | |
| Ethenzamide SCHEMBL4379591 | 0.81 | MAPT (0.66) | MAPTMAPK1GAAHCRTR1MEN1 | |
| Ethenzamide SCHEMBL22163775 | 0.81 | MAPT (0.66) | MAPTMAPK1GAAHCRTR1MEN1 | |
| Ethenzamide SCHEMBL5401172 | 0.81 | MAPT (0.66) | MAPTMAPK1GAAHCRTR1MEN1 | |
| SCHEMBL6332463 | 0.80 | MAPT (0.54) | MAPTMAPK1GAAKCNK3KCNK9 | |
| SCHEMBL2358299 | 0.80 | HCRTR1 (0.73) | MAPTMAPK1GAAKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562830-B1 | Compounds which prevent or induce the remission of existing precancerous or cancerous lesions or carcinomas would greatly reduce illness and death from cancer | CELL PATHWAYS, INC. | 2003-05-13 | — | — | US | disclosed |
| EP-0628032-B1 | QUINAZOLINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1998-05-13 | — | — | EP | disclosed |
| US-5482941-A | Quinazolinone antianginal agents | PFIZER INC. (US) | 1996-01-09 | — | — | US | disclosed |
| EP-0628032-A1 | QUINAZOLINONE ANTIANGINAL AGENTS | Pfizer Limited (GB) | 1994-12-14 | — | — | EP | disclosed |
| WO-1993012095-A1 | QUINAZOLINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1993-06-24 | — | — | WO | disclosed |