Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 8/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | FABP2 | P12104 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348404 | 0.80 | AKR1C3 (0.63) | NPSR1PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL4949023 | 0.80 | AKR1C3 (0.63) | NPSR1PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL2918748 | 0.80 | AKR1C3 (0.63) | NPSR1PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL12406125 | 0.80 | GRIA4 (0.54) | GRIA4NPSR1PTPRCPTPN1PTGS1 | |
| SCHEMBL11831580 | 0.79 | PTPRC (0.45) | GRIA4NPSR1PTPRCPTPN1PTGS1 | |
| SCHEMBL11805589 | 0.79 | GRIA4 (0.58) | GRIA4NPSR1PTPRCPTPN1PTGS1 | |
| SCHEMBL28583379 | 0.78 | CYP2C19 (0.36) | GRIA4PTGS1MEN1PTGS2KMT2A | |
| SCHEMBL10594958 | 0.77 | PTGS2 (0.53) | GRIA4PTGS2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29595346 | 0.77 | TYR (0.41) | GRIA4PTGS2ERN1 | |
| SCHEMBL24438785 | 0.77 | GRIA4 (0.51) | GRIA4NPSR1PTPRCPTPN1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552086-B1 | For therapy of psychiatric and neurological disorders | ELI LILLY AND COMPANY | 2003-04-22 | — | — | US | disclosed |
| EP-1115393-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000006149-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| US-4191776-A | ANTITHROMBOTICS, ANTICHOLESTEREMICS, ANTICOAGULANTS | BOEHRINGER INGELHEIM GMBH (DE) | 1980-03-04 | — | — | US | disclosed |