Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.48 |
| ▸ | FLT4 | P35916 | 4/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 11/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673375 | 0.80 | KDR (0.66) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL16760390 | 0.79 | ENPP1 (0.68) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL4593476 | 0.79 | ENPP1 (0.59) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL4590452 | 0.79 | ENPP1 (0.59) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL19372996 | 0.77 | KDR (0.61) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL14506813 | 0.76 | ENPP1 (0.56) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL31193365 | 0.76 | ENPP1 (0.56) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL29685619 | 0.76 | ENPP1 (0.59) | ENPP1KDREGFRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL23355322 | 0.75 | ENPP1 (0.55) | ENPP1KDREGFRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL28983494 | 0.75 | ENPP1 (0.58) | ENPP1KDREGFRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272185-A2 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001066099-A2 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2001-09-13 | — | — | WO | disclosed |