Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.66 |
| ▸ | SRC | P12931 | 5/20 | 0.66 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | FLT1 | P17948 | 3/20 | 0.55 |
| ▸ | FLT4 | P35916 | 3/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 11/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KIF5B | P33176 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3206677 | 0.87 | KDR (0.79) | KDRSRCEGFRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL7591152 | 0.86 | KDR (0.78) | KDRSRCEGFRFGFR1FLT1 | |
| SCHEMBL7580342 | 0.81 | SRC (0.76) | KDRSRCEGFRFLT1EPHA2 | |
| SCHEMBL7580350 | 0.81 | SRC (0.76) | KDRSRCEGFRFLT1EPHA2 | |
| SCHEMBL7572205 | 0.81 | SRC (0.76) | KDRSRCEGFRFLT1EPHA2 | |
| SCHEMBL7167285 | 0.80 | ENPP1 (0.55) | KDREGFRFGFR1FLT1FLT4 | |
| Azm-475271 SCHEMBL29388701 | 0.80 | KDR (1.00) | KDRSRCEGFRFGFR1FLT1 | |
| Azm-475271 SCHEMBL3195079 | 0.80 | KDR (1.00) | KDRSRCEGFRFGFR1FLT1 | |
| SCHEMBL7573786 | 0.76 | SRC (0.80) | KDRSRCEGFRFLT1EPHA2 | |
| SCHEMBL3186078 | 0.76 | KDR (0.71) | KDRSRCEGFRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562612-B1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE FOR USE IN THE TREATMENT OR PROPHLAXIX OF PANCREATIC CANCER | ASTRAZENECA AB (SE) | 2010-01-27 | — | — | EP | disclosed |