SCHEMBL716756

SCHEMBL716756

CC(=O)Oc1ccc(C=Cc2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.71
LMNA P02545 3/20 0.71
MAPT P10636 2/20 0.71
KDM4E B2RXH2 2/20 0.71
MEN1 O00255 1/20 0.71
TTR P02766 1/20 0.71
TP53 P04637 1/20 0.71
CYP3A4 P08684 1/20 0.71
SMN1; SMN2 Q16637 1/20 0.71
ELANE P08246 1/20 0.61
TUBB4A P04350 3/20 0.59
TUBB P07437 3/20 0.59
TUBA3C P0DPH7 3/20 0.59
TUBA1B P68363 3/20 0.59
TUBA4A P68366 3/20 0.59
TUBB4B P68371 3/20 0.59
TUBB3 Q13509 3/20 0.59
TUBB2A Q13885 3/20 0.59
TUBB8 Q3ZCM7 3/20 0.59
TUBA3E Q6PEY2 3/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL716755 1.00 KMT2A (0.71) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL10941162 0.92 MAPT (0.81) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL2451780 0.92 MAPT (0.81) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL11354408 0.92 MAPT (0.81) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL10943198 0.89 LMNA (0.72) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL10941170 0.89 KMT2A (0.67) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL9669873 0.89 ELANE (0.61) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL9248649 0.88 KMT2A (0.61) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL28941586 0.87 KMT2A (0.59) KMT2ALMNAMAPTKDM4EMEN1
SCHEMBL28941587 0.87 KMT2A (0.59) KMT2ALMNAMAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2020-06-18 US disclosed
US-9763961-B2 Compositions that modulate the activity of estrogen receptors and estrogen-related receptors and methods for use CITY OF HOPE (US) 2017-09-19 US disclosed
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-10-06 US disclosed
US-8227635-B2 Apparatus and method for carrying out multiple reactions UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2012-07-24 US disclosed
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS MONASH UNIVERSITY (AU) 2012-03-01 US disclosed
US-7914890-B2 Cyclic olefin-maleic acid copolymers for stain resists E.I. DUPONT DE NEMOURS AND COMPANY (US) 2011-03-29 US disclosed
US-20090299102-A1 APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2009-12-03 US disclosed
US-20090162682-A1 Cyclic olefin-maleic acid copolymers for stain resists E. I. DU PONT DE NEMOURS AND COMPANY 2009-06-25 US disclosed
US-7531578-B2 Acetic acid 4-{1-[4-(2-dimethylamino-ethoxy)-phenyl]-2-phenyl-but-1-enyl}-phenyl ester; estrogen related receptor (ERR beta or ERR gamma) antagonist; thirty times more effective than 4-hydroxytamoxifen CITY OF HOPE (US) 2009-05-12 US disclosed
EP-1495182-B1 REPELLENT FLUOROCHEMICAL COMPOSITIONS 3M INNOVATIVE PROPERTIES CO (US) 2008-08-27 EP disclosed
EP-0328822-B1 STAIN-RESISTANT AGENTS FOR TEXTILES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-04-21 EP disclosed
EP-0531313-A1 AQUEOUS SOLUTIONS OF HYDROLYZED MALEIC ANHYDRIDE COPOLYMERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-03-17 EP disclosed
WO-1992012286-A1 MALEIC ANHYDRIDE/VINYL OR ALLYL ETHER POLYMER STAIN-RESISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-07-23 WO disclosed
WO-1991018932-A1 AQUEOUS SOLUTIONS OF HYDROLYZED MALEIC ANHYDRIDE COPOLYMERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-12-12 WO disclosed
US-5032136-A Hydrolyzed maleic anhydride copolymer, sulfonated phenol-formaldehyde condensate E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-07-16 US disclosed
US-5001004-A Polyamides textile substrates resistant to staining by acid dyes E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-03-19 US disclosed
US-4948650-A SULFONATED PHENOL-FORMALDEHYDE AND ETHYLENICALLY UNSATURATED MONOMER E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-14 US disclosed
US-4883839-A SULFONATED PHENOL-FORMALDEHYDE RESIN, HYDROLYZED MALEIC ANHYDRIDE-STYRENE COPOLYMER, CARPET E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-11-28 US disclosed
EP-0329899-A2 Stain-resistant aromatic/maleic anhydride polymers E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-08-30 EP disclosed
EP-0328822-A2 Stain-resistant agents for textiles E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-08-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160288090-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 KMT2A 964/4885LMNA 3479/4885MAPT 3368/4885
US-20090299102-A1 APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS DDO, APEX1, MMAB KMT2A 922/4885LMNA 2480/4885MAPT 3797/4885
US-20120052757-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 KMT2A 964/4885LMNA 3479/4885MAPT 3368/4885
US-20200188878-A1 MOLECULARLY IMPRINTED POLYMERS IPMK, MPI, PIM3 KMT2A 964/4885LMNA 3479/4885MAPT 3368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.