Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.66 |
| ▸ | STAT3 | P40763 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12283339 | 0.79 | STAT3 (0.57) | STAT3ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL29803055 | 0.79 | STAT3 (0.57) | STAT3ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL1098076 | 0.79 | STAT3 (0.57) | STAT3ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL22510018 | 0.79 | STAT3 (0.57) | STAT3ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL21643363 | 0.79 | STAT3 (0.57) | STAT3ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL25287579 | 0.77 | STAT3 (0.61) | STAT3ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL25287578 | 0.77 | STAT3 (0.61) | STAT3ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL10695936 | 0.77 | PTAFR (0.52) | CYP51A1STAT3MAPK1ALDH1A1NPSR1 | |
| SCHEMBL10881714 | 0.76 | CYP51A1 (0.51) | CYP51A1MAPK1ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL10705171 | 0.75 | SMN1; SMN2 (0.56) | CYP51A1MAPK1ALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030235889-A1 | Materials and methods involving conditional retention domains | ARIAD GENE THERAPEUTICS, INC. | 2003-12-25 | — | — | US | disclosed |
| US-6566073-B1 | Induction of preferential protein in cells; obtain genetically engineered cell, incubate with ligand and monitor expression of preferential protein | ARIAD GENE THERAPEUTICS, INC. | 2003-05-20 | — | — | US | disclosed |
| EP-1144655-A2 | REGULATED EXPRESSION USING CONDITIONAL ER RETENTION DOMAINS | ARIAD GENE THERAPEUTICS, INC. (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-1123405-A1 | MATERIALS AND METHODS INVOLVING CONDITIONAL AGGREGATION DOMAINS | ARIAD GENE THERAPEUTICS, INC. (US) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000023602-A2 | REGULATED EXPRESSION USING CONDITIONAL ER RETENTION DOMAINS | ARIAD GENE THERAPEUTICS, INC. (US) | 2000-04-27 | — | — | WO | disclosed |
| WO-2000023600-A1 | MATERIALS AND METHODS INVOLVING CONDITIONAL AGGREGATION DOMAINS | ARIAD GENE THERAPEUTICS, INC. (US) | 2000-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030235889-A1 | Materials and methods involving conditional retention domains | KDELR1, KDELR2, CD2BP2 | CYP51A1 4617/4885STAT3 3785/4885MAPK1 4729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.