Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1A | P50416 | 14/20 | 0.60 |
| ▸ | CPT2 | P23786 | 13/20 | 0.60 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.56 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11481661 | 1.00 | CPT1A (0.60) | CPT1ACPT2CPT1BSPHK2SPHK1 | |
| SCHEMBL3148212 | 0.89 | ALDH1A1 (0.63) | CPT1ACPT2CPT1BMEN1KMT2A | |
| SCHEMBL5743864 | 0.89 | ALDH1A1 (0.63) | CPT1ACPT2CPT1BMEN1KMT2A | |
| SCHEMBL14948377 | 0.86 | CPT1A (0.60) | CPT1ACPT2CPT1BMEN1KMT2A | |
| SCHEMBL11424895 | 0.85 | CPT1A (0.67) | CPT1ACPT2CPT1B | |
| SCHEMBL31710554 | 0.84 | DPP4 (0.59) | CPT1ACPT2CPT1BSPHK2SPHK1 | |
| SCHEMBL9094912 | 0.83 | CPT2 (0.62) | CPT1ACPT2CPT1B | |
| SCHEMBL9094927 | 0.83 | CPT2 (0.62) | CPT1ACPT2CPT1B | |
| SCHEMBL3187180 | 0.83 | ALDH1A1 (0.61) | CPT1ACPT2MEN1KMT2A | |
| SCHEMBL3187156 | 0.83 | ALDH1A1 (0.61) | CPT1ACPT2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |