Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.38 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28794531 | 1.00 | KDM4E (0.44) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL2865720 | 1.00 | KDM4E (0.44) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL2863141 | 1.00 | KDM4E (0.44) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL28945606 | 1.00 | KDM4E (0.44) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL2864654 | 0.97 | — | — | |
| SCHEMBL7463711 | 0.90 | — | — | |
| Ethylene SCHEMBL10456946 | 0.87 | KDM4E (0.50) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL15871737 | 0.87 | KDM4E (0.55) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL20836564 | 0.87 | KDM4E (0.55) | KDM4EMAPK1HIF1APRMT1ALDH1A1 | |
| SCHEMBL5569558 | 0.87 | KDM4E (0.55) | KDM4EMAPK1HIF1APRMT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | SHISEIDO COMPANY LTD. (JP) | 2007-09-27 | — | — | US | claimed |
| EP-1688126-A1 | PARAKERATOSIS INHIBITOR AND EXTERNAL COMPOSITION FOR SKIN | SHISEIDO COMPANY LIMITED (JP) | 2006-08-09 | — | — | EP | claimed |
| WO-2023068090-A1 | AGENT FOR IMPROVING SAGGING PORES | 株式会社 資生堂 | 2023-04-27 | — | — | WO | disclosed |
| US-9533195-B2 | Golf ball | DUNLOP SPORTS CO. LTD. (JP) | 2017-01-03 | — | — | US | disclosed |
| US-20160144241-A1 | GOLF BALL | DUNLOP SPORTS CO. LTD. (JP) | 2016-05-26 | — | — | US | disclosed |
| US-9283439-B2 | Golf ball | DUNLOP SPORTS CO., LTD. (JP) | 2016-03-15 | — | — | US | disclosed |
| US-20140206476-A1 | GOLF BALL | DUNLOP SPORTS CO. LTD. (JP) | 2014-07-24 | — | — | US | disclosed |
| US-8586638-B2 | Parakeratosis inhibitor and skin preparation for external use | SHISEIDO COMPANY, LTD (JP) | 2013-11-19 | — | — | US | disclosed |
| US-8586638-B2 | Parakeratosis inhibitor and skin preparation for external use | SHISEIDO COMPANY, LTD (JP) | 2013-11-19 | — | — | US | disclosed |
| US-20120253064-A1 | PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE | SHISEIDO COMPANY, LTD. (JP) | 2012-10-04 | — | — | US | disclosed |
| EP-2491981-A2 | Parakeratosis inhibitor and external composition for skin | SHISEIDO COMPANY LIMITED (JP) | 2012-08-29 | — | — | EP | disclosed |
| CN-1886114-B | Parakeratosis inhibitor and composition for external use on skin | SHISEIDO CO LTD | 2011-08-10 | — | — | CN | disclosed |
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | SHISEIDO COMPANY LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | SHISEIDO COMPANY LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| CN-1886114-A | Parakeratosis inhibitor and composition for external use on skin | SHISEIDO CO LTD (JP) | 2006-12-27 | — | — | CN | disclosed |
| EP-1688126-A1 | PARAKERATOSIS INHIBITOR AND EXTERNAL COMPOSITION FOR SKIN | SHISEIDO COMPANY LIMITED (JP) | 2006-08-09 | — | — | EP | disclosed |
| EP-1688126-A1 | PARAKERATOSIS INHIBITOR AND EXTERNAL COMPOSITION FOR SKIN | SHISEIDO COMPANY LIMITED (JP) | 2006-08-09 | — | — | EP | disclosed |
| JP-2005179342-A | PARAKERATOSIS-SUPPRESSING AGENT AND PORE SHRINKING AGENT | SHISEIDO CO LTD | 2005-07-07 | — | — | JP | disclosed |
| WO-2005051340-A1 | PARAKERATOSIS INHIBITOR AND EXTERNAL COMPOSITION FOR SKIN | SHISEIDO COMPANY, LTD. (JP) | 2005-06-09 | — | — | WO | disclosed |
| US-4976679-A | CATALYTIC REACTION OF PRIMARY AMINE, HYDROXYL COMPOUND, CARBON MONOXIDE, AND OXYGEN | MITSUBISHI GAS CHEMICAL COMPANY, INC., A CORP. OF JAPAN (JP) | 1990-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120253064-A1 | PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE | CUTA, HPN, PRSS1 | KDM4E 1142/4885MAPK1 2138/4885HIF1A 1477/4885 |
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | CUTA, HPN, DNPEP | KDM4E 644/4885MAPK1 2285/4885HIF1A 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.