Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166811 | 0.84 | KMT2A (0.52) | HTR7MKNK1MKNK2KMT2AMEN1 | |
| SCHEMBL6169123 | 0.84 | KMT2A (0.52) | HTR7MKNK1MKNK2KMT2AMEN1 | |
| SCHEMBL4375475 | 0.77 | KMT2A (0.51) | HTR7HTR2CKMT2AMEN1POLB | |
| SCHEMBL2598587 | 0.77 | KMT2A (0.62) | HTR7MKNK1MKNK2KMT2AMEN1 | |
| SCHEMBL12520465 | 0.76 | KMT2A (0.56) | HTR7MKNK1MKNK2KMT2AMEN1 | |
| SCHEMBL15130901 | 0.75 | KMT2A (0.74) | KMT2AMEN1POLBSLC2A1RAD52 | |
| SCHEMBL25570805 | 0.75 | KMT2A (0.74) | KMT2AMEN1POLBSLC2A1RAD52 | |
| SCHEMBL30579418 | 0.75 | CCNT1 (0.67) | HTR7MKNK1MKNK2KMT2AMEN1 | |
| SCHEMBL34462772 | 0.74 | HTR1A (0.57) | HTR7MKNK1MKNK2KMT2AMEN1 | |
| SCHEMBL34462801 | 0.74 | HTR1A (0.64) | HTR7MKNK1MKNK2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |