Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.45 |
| ▸ | NR0B2 | Q15466 | 3/20 | 0.45 |
| ▸ | RARB | P10826 | 4/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | RARA | P10276 | 3/20 | 0.34 |
| ▸ | RARG | P13631 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.33 |
| ▸ | GOT1 | P17174 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7169523 | 1.00 | PTPN11 (0.45) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2406294 | 0.83 | PTPN11 (0.64) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2406297 | 0.83 | PTPN11 (0.64) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL6022897 | 0.77 | HDAC11 (0.47) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL6022901 | 0.77 | HDAC11 (0.47) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2404992 | 0.73 | PTPN11 (0.58) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2404988 | 0.73 | PTPN11 (0.58) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2393698 | 0.72 | PTPN11 (0.50) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2393700 | 0.70 | PTPN11 (0.57) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL27620046 | 0.70 | RARB (0.49) | PTPN11NR0B2RARBHDAC11HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456165-A1 | INDUCTION OF APOPTOSIS IN CANCER CELLS | The Burnham Institute (US) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003048101-A1 | INDUCTION OF APOPTOSIS IN CANCER CELLS | THE BURNHAM INSTITUTE (US) | 2003-06-12 | — | — | WO | disclosed |