Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Torcetrapib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP known ✓ | P11597 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Torcetrapib SCHEMBL10041443 | 1.00 | CETP (1.00) | CETP | |
| Torcetrapib SCHEMBL49081 | 1.00 | CETP (1.00) | CETP | |
| Torcetrapib SCHEMBL126708 | 1.00 | CETP (1.00) | CETP | |
| Torcetrapib SCHEMBL29403162 | 1.00 | CETP (1.00) | CETP | |
| Torcetrapib SCHEMBL6277910 | 1.00 | CETP (1.00) | CETP | |
| SCHEMBL18027496 | 0.97 | CETP (0.94) | CETP | |
| SCHEMBL12756768 | 0.96 | CETP (0.92) | CETP | |
| Torcetrapib SCHEMBL3185801 | 0.96 | CETP (0.92) | CETP | |
| Torcetrapib SCHEMBL3187101 | 0.96 | CETP (0.92) | CETP | |
| Torcetrapib SCHEMBL3187095 | 0.96 | CETP (0.92) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573383-B2 | Preparation of anhydrous CETP inhibitor | PFIZER INC | 2003-06-03 | — | — | US | disclosed |