Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Torcetrapib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP known ✓ | P11597 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Torcetrapib SCHEMBL49081 | 1.00 | CETP (1.00) | CETP | |
| Torcetrapib SCHEMBL6277910 | 1.00 | CETP (1.00) | CETP | |
| Torcetrapib SCHEMBL7169875 | 1.00 | CETP (1.00) | CETP | |
| Torcetrapib SCHEMBL29403162 | 1.00 | CETP (1.00) | CETP | |
| Torcetrapib SCHEMBL126708 | 1.00 | CETP (1.00) | CETP | |
| SCHEMBL18027496 | 0.97 | CETP (0.94) | CETP | |
| Torcetrapib SCHEMBL3185801 | 0.96 | CETP (0.92) | CETP | |
| SCHEMBL12756768 | 0.96 | CETP (0.92) | CETP | |
| Torcetrapib SCHEMBL3187101 | 0.96 | CETP (0.92) | CETP | |
| Torcetrapib SCHEMBL3187095 | 0.96 | CETP (0.92) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207232-B2 | Pharmaceutical compositions with enhanced performance | BEND RESEARCH, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20080262107-A1 | A solid amorphous dispersion of a low-soluble drug and hydroxypropylmethyl celllulose acetate succinate with an ester degree of substitution of 0.85 which results in concentration-enhancement, time release agents, and storage stability; rapid crystal growth inhibitors in supersaturated aqueous solutions | PFIZER PRODUCTS INC. (US) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262107-A1 | A solid amorphous dispersion of a low-soluble drug and hydroxypropylmethyl celllulose acetate succinate with an ester degree of substitution of 0.85 which results in concentration-enhancement, time release agents, and storage stability; rapid crystal growth inhibitors in supersaturated aqueous solutions | HPD, HAAO, SUCLA2 | CETP 2024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.