Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.39 |
| ▸ | MMP13 | P45452 | 5/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095095 | 0.79 | USP2 (0.39) | USP2SMN1; SMN2GPR119HPGDEPHX2 | |
| SCHEMBL7169881 | 0.72 | CYP4F2 (0.46) | USP2SMN1; SMN2GPR119MMP13ADAM17 | |
| SCHEMBL13232132 | 0.72 | USP2 (0.53) | USP2SMN1; SMN2GPR119HPGDEPHX2 | |
| SCHEMBL346995 | 0.71 | USP2 (0.56) | USP2SMN1; SMN2GPR119HPGDEPHX2 | |
| SCHEMBL3436829 | 0.71 | USP2 (0.56) | USP2SMN1; SMN2GPR119HPGDEPHX2 | |
| SCHEMBL2204005 | 0.71 | USP2 (0.49) | USP2SMN1; SMN2GPR119HPGDEPHX2 | |
| SCHEMBL17861638 | 0.71 | USP2 (0.45) | USP2SMN1; SMN2GPR119HPGDEPHX2 | |
| SCHEMBL597478 | 0.71 | GPR4 (0.46) | USP2SMN1; SMN2GPR119HPGDEPHX2 | |
| SCHEMBL1575709 | 0.71 | CYP4F2 (0.47) | USP2SMN1; SMN2GPR119HPGDEPHX2 | |
| SCHEMBL21644242 | 0.71 | CYP4F2 (0.47) | USP2SMN1; SMN2GPR119HPGDEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286967-A1 | CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001087838-A1 | CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-22 | — | — | WO | disclosed |