Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8383139 | 1.00 | KCNH2 (0.34) | KCNH2SLC6A2CHRNB2CHRNA4SLC6A4 | |
| Hydrochloric Acid SCHEMBL9480501 | 0.98 | KCNH2 (0.34) | KCNH2SLC6A2CHRNB2CHRNA4SLC6A4 | |
| Hydrochloric Acid SCHEMBL10766371 | 0.98 | KCNH2 (0.34) | KCNH2SLC6A2CHRNB2CHRNA4SLC6A4 | |
| Hydrochloric Acid SCHEMBL9480862 | 0.98 | KCNH2 (0.34) | KCNH2SLC6A2CHRNB2CHRNA4SLC6A4 | |
| SCHEMBL12184324 | 0.77 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3PRKAB2PRKAG1 | |
| Hydrochloric Acid SCHEMBL2589524 | 0.76 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3PRKAB2PRKAG1 | |
| SCHEMBL10368468 | 0.75 | CHRNB2 (0.40) | KCNH2SLC6A2CHRNB2CHRNA4SLC6A4 | |
| SCHEMBL10368470 | 0.75 | CHRNB2 (0.40) | KCNH2SLC6A2CHRNB2CHRNA4SLC6A4 | |
| Hydrochloric Acid SCHEMBL10370902 | 0.74 | CHRNB2 (0.39) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL10370903 | 0.74 | CHRNB2 (0.39) | SLC6A2CHRNB2CHRNA4SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460912-A2 | Medicaments for the treatment of sexual disorder | GLAXO GROUP LIMITED (GB) | 1991-12-11 | — | — | EP | claimed |
| EP-0224332-B1 | HETEROCYCLIC AMINO COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1990-08-08 | — | — | EP | claimed |
| EP-0655914-B1 | Use of Histamine-2 agonists for treatment of sexual dysfunction | NAHOUM CESAR ROBERTO DIAS (BR) | 2003-02-26 | — | — | EP | disclosed |
| EP-0655914-A4 | NOVEL COMPOSITIONS. | NAHOUM CESAR ROBERTO DIAS (BR) | 1998-04-22 | — | — | EP | disclosed |
| EP-0655914-A1 | NOVEL COMPOSITIONS | NAHOUM, Cesar Roberto Dias (BR) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004120-A2 | METHODS OF TREATING SEXUAL DYSFUNCTION IN ANIMALS WITH AND H AGONIST | NAHOUM CESAR ROBERTO DIAS (BR) | 1994-03-03 | — | — | WO | disclosed |
| EP-0224332-A1 | Heterocyclic amino compounds | GLAXO GROUP LIMITED (GB) | 1987-06-03 | — | — | EP | disclosed |