Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SCD | O00767 | 2/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CTPS1 | P17812 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3617632 | 0.86 | GAA (0.58) | GAAL3MBTL1ALDH1A1SCDPTGES2 | |
| SCHEMBL3248035 | 0.71 | GAA (0.59) | GAAL3MBTL1ALDH1A1SCDPTGES2 | |
| SCHEMBL12620551 | 0.68 | ALDH1A1 (0.55) | GAAL3MBTL1ALDH1A1PTGES2POLB | |
| SCHEMBL5132405 | 0.67 | GAA (0.54) | GAAL3MBTL1ALDH1A1PTGES2POLB | |
| SCHEMBL3622307 | 0.66 | KMT2A (0.65) | GAAALDH1A1POLBMAPTCTPS1 | |
| SCHEMBL4244410 | 0.66 | ALDH1A1 (0.53) | GAAL3MBTL1ALDH1A1PTGES2POLB | |
| SCHEMBL2058323 | 0.66 | ALDH1A1 (0.74) | GAAL3MBTL1ALDH1A1PTGES2POLB | |
| SCHEMBL3617616 | 0.65 | KDM1A (0.57) | GAAALDH1A1SCDPOLBMAPT | |
| SCHEMBL3620479 | 0.65 | POLB (0.53) | GAAALDH1A1SCDPOLBMAPT | |
| SCHEMBL9481455 | 0.65 | CTPS1 (0.62) | GAAALDH1A1MAPTCTPS1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283831-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001090090-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2001-11-29 | — | — | WO | disclosed |