Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 12/20 | 0.61 |
| ▸ | ICAM1 | P05362 | 12/20 | 0.61 |
| ▸ | ITGAL | P20701 | 12/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.35 |
| ▸ | PLD2 | O14939 | 1/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170389 | 0.83 | ITGB2 (0.75) | ITGB2ICAM1ITGALKDM4ETDP1 | |
| SCHEMBL7143425 | 0.71 | ITGAL (0.74) | ITGB2ICAM1ITGAL | |
| SCHEMBL7144870 | 0.69 | ITGB2 (0.70) | ITGB2ICAM1ITGAL | |
| SCHEMBL2963974 | 0.65 | CA1 (0.42) | KDM4ETDP1 | |
| SCHEMBL6199566 | 0.65 | ITGAL (0.51) | ITGB2ICAM1ITGAL | |
| SCHEMBL7147403 | 0.63 | ITGB2 (0.50) | ITGB2ICAM1ITGAL | |
| SCHEMBL6792300 | 0.62 | MMP2 (0.60) | TDP1 | |
| SCHEMBL4278725 | 0.62 | ITGAL (0.67) | ITGB2ICAM1ITGALKDM4E | |
| SCHEMBL4278719 | 0.62 | ITGAL (0.67) | ITGB2ICAM1ITGALKDM4E | |
| Hydrogen Peroxide SCHEMBL28640288 | 0.62 | CA1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521619-B2 | Bind to the interaction-domain of integrin lfa-1 interrupting enothelial cell-leukocyte adhesion | ICOS CORPORATION | 2003-02-18 | — | — | US | claimed |