SCHEMBL7171602

SCHEMBL7171602

Cc1noc(=O)c2ccc(NC(=O)C(O)(CC3(c4cc(F)ccc4Cl)CC3)C(F)(F)F)cc12.Cc1noc(=O)c2ccc(NC(=O)C(O)(CC3(c4ccc(F)cc4Cl)CCC3)C(F)(F)F)cc12

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 0.57
PGR P06401 1/20 0.55
NR3C2 P08235 1/20 0.55
AR P10275 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7172663 0.97 NR3C1 (0.60) NR3C1PGRNR3C2AR
SCHEMBL7168666 0.97 NR3C1 (0.60) NR3C1PGRNR3C2AR
SCHEMBL7202627 0.96 NR3C1 (0.55) NR3C1PGRNR3C2AR
SCHEMBL5644212 0.96 NR3C1 (0.61) NR3C1PGRNR3C2AR
SCHEMBL5641657 0.96 NR3C1 (0.61) NR3C1PGRNR3C2AR
SCHEMBL5641687 0.95 NR3C1 (0.60) NR3C1PGRNR3C2AR
SCHEMBL5642753 0.95 NR3C1 (0.60) NR3C1PGRNR3C2AR
SCHEMBL5643349 0.90 NR3C1 (0.59) NR3C1PGRNR3C2AR
SCHEMBL5644427 0.90 NR3C1 (0.61) NR3C1
SCHEMBL5642293 0.89 NR3C1 (0.69) NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1309571-A1 NON-STEROIDAL INFLAMMATION INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 2003-05-14 EP disclosed
WO-2002010143-A1 NON-STEROIDAL INFLAMMATION INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 2002-02-07 WO disclosed