Sugi Predict

Sugi Predict / Compounds / Urea

Urea

Urea

SCHEMBL717178

CCCCNC(=O)NCc1ccccc1.NC(N)=O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 2/20 0.67
▸ EPHX1 P07099 4/20 0.61
▸ SMN1; SMN2 Q16637 1/20 0.57
▸ KEAP1 Q14145 1/20 0.55
▸ NFE2L2 Q16236 1/20 0.55
▸ CA12 O43570 1/20 0.53
▸ CA1 P00915 1/20 0.53
▸ CA2 P00918 1/20 0.53
▸ CA4 P22748 1/20 0.53
▸ CA5A P35218 1/20 0.53
▸ CA7 P43166 1/20 0.53
▸ CA9 Q16790 1/20 0.53
▸ CA14 Q9ULX7 1/20 0.53
▸ PPID Q08752 1/20 0.52
▸ HTT P42858 2/20 0.51
▸ ALDH1A1 P00352 1/20 0.51
▸ PTPN1 P18031 1/20 0.51
▸ POLB P06746 2/20 0.50
▸ TSHR P16473 1/20 0.50
▸ BACE1 P56817 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3421197 0.95 EPHX2 (0.73) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2
SCHEMBL4985255 0.90 EPHX2 (0.71) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2
SCHEMBL3420583 0.89 EPHX2 (0.69) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2
SCHEMBL3403502 0.89 EPHX2 (0.69) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2
SCHEMBL11035774 0.89 EPHX2 (0.69) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2
SCHEMBL11260446 0.89 EPHX2 (0.69) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2
SCHEMBL1134902 0.85 EPHX1 (0.71) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2
SCHEMBL6435482 0.85 EPHX2 (0.83) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2
SCHEMBL2702269 0.84 EPHX2 (0.57) EPHX2EPHX1SMN1; SMN2HTTPOLB
SCHEMBL6438376 0.83 EPHX2 (0.80) EPHX2EPHX1SMN1; SMN2KEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120053342-A1 METHOD FOR MAKING CARBAMATES, UREAS AND ISOCYANATES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-03-01 — — US disclosed
US-8058469-B2 Method for making carbamates, ureas and isocyanates SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2011-11-15 — — US disclosed
CN-102203050-A Method for making carbamates, ureas and isocyanates SABIC INNOVATIVE PLASTICS IP 2011-09-28 — — CN disclosed
EP-2362867-A2 METHOD FOR MAKING CARBAMATES, UREAS AND ISOCYANATES SABIC Innovative Plastics IP B.V. (NL) 2011-09-07 — — EP disclosed
WO-2010062490-A2 METHOD FOR MAKING CARBAMATES, UREAS AND ISOCYANATES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-06-03 — — WO disclosed
US-20100113819-A1 Method for Making Carbamates, Ureas and Isocyanates SABIC INNOVATIVE PLASTICS IP BV (NL) 2010-05-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100113819-A1 Method for Making Carbamates, Ureas and Isocyanates CPS1, ALKBH3, KDM8 EPHX2 1192/4885EPHX1 2421/4885SMN1; SMN2 4243/4885
US-20120053342-A1 METHOD FOR MAKING CARBAMATES, UREAS AND ISOCYANATES CPS1, ALKBH3, IDH3A EPHX2 1306/4885EPHX1 2542/4885SMN1; SMN2 4218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.