Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7178094 | 0.89 | CYP2C9 (0.34) | — | |
| SCHEMBL7178095 | 0.89 | CYP2C9 (0.34) | — | |
| SCHEMBL3380328 | 0.83 | HDAC1 (0.40) | HDAC6HDAC8HDAC1HDAC3HDAC4 | |
| SCHEMBL13783872 | 0.83 | HDAC1 (0.40) | HDAC6HDAC8HDAC1HDAC3HDAC4 | |
| SCHEMBL7175453 | 0.82 | AOC3 (0.36) | — | |
| SCHEMBL7176011 | 0.79 | HDAC8 (0.47) | HDAC6HDAC8HDAC1HDAC3HDAC4 | |
| SCHEMBL13783862 | 0.72 | HDAC1 (0.36) | HDAC8HDAC1 | |
| SCHEMBL3380886 | 0.72 | HDAC1 (0.36) | HDAC8HDAC1 | |
| SCHEMBL3379481 | 0.71 | ALOX5 (0.35) | HDAC8HDAC1 | |
| SCHEMBL13783860 | 0.71 | ALOX5 (0.35) | HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280764-A2 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001070675-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2001-09-27 | — | — | WO | disclosed |