Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 6/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172429 | 1.00 | LMNA (0.48) | LMNAPDE4BPDE4DALDH1A1POLB | |
| SCHEMBL7170246 | 0.89 | PDE4B (0.53) | LMNAPDE4BPDE4DALDH1A1POLB | |
| SCHEMBL7170243 | 0.89 | PDE4B (0.53) | LMNAPDE4BPDE4DALDH1A1POLB | |
| SCHEMBL7174936 | 0.87 | PDE4B (0.66) | LMNAPDE4BPDE4DALDH1A1POLB | |
| SCHEMBL7177909 | 0.87 | PDE4B (0.66) | LMNAPDE4BPDE4DALDH1A1POLB | |
| SCHEMBL7175061 | 0.87 | PDE4B (0.66) | LMNAPDE4BPDE4DALDH1A1POLB | |
| SCHEMBL7170256 | 0.86 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7174439 | 0.86 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7178980 | 0.86 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7171526 | 0.86 | PDE4B (0.50) | LMNAPDE4BPDE4DALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900212-B1 | CHIRAL PHENYLDIHYDROFURANONES AS PDE-IV INHIBITORS | SCHERING AG (DE) | 2003-12-17 | — | — | EP | claimed |
| US-6011060-A | TREATING A DISEASE MEDIATED BY ACTIVATION OF THE TUMOR NECROSIS FACTOR | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-01-04 | — | — | US | claimed |
| EP-0900212-B1 | CHIRAL PHENYLDIHYDROFURANONES AS PDE-IV INHIBITORS | SCHERING AG (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-6011060-A | TREATING A DISEASE MEDIATED BY ACTIVATION OF THE TUMOR NECROSIS FACTOR | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-01-04 | — | — | US | disclosed |