Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.96 |
| ▸ | LMNA | P02545 | 4/20 | 0.96 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | APEX1 | P27695 | 1/20 | 0.96 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | LIPE | Q05469 | 4/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.48 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.48 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL240269 | 0.98 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL29494845 | 0.98 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL8686510 | 0.89 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL12386871 | 0.89 | LMNA (0.83) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL5647172 | 0.89 | MAPK1 (1.00) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL10854830 | 0.88 | MAPK1 (0.97) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL5646896 | 0.85 | SMN1; SMN2 (0.75) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL10954112 | 0.84 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL5648867 | 0.83 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL11016705 | 0.83 | SMN1; SMN2 (0.72) | SMN1; SMN2LMNACYP2C9TSHRAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579686-B2 | Detecting modulators of clotrimazole binding; mix modulator, clotrimazole and receptor, determine amount of clotrimazole bound to receptor, reduction in clotrimazole binding indicate a modulator of binding activity | SMITHKLINE BEECHAM CORPORATION | 2003-06-17 | — | — | US | disclosed |
| US-20010055815-A1 | Constitutive androstane receptor | COLLINS JON L (US) | 2001-12-27 | — | — | US | disclosed |
| WO-2001071361-A2 | CONSTITUTIVE ANDROSTANE RECEPTOR | GLAXO GROUP LIMITED (GB) | 2001-09-27 | — | — | WO | disclosed |