Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 10/20 | 0.78 |
| ▸ | CDK2 | P24941 | 6/20 | 0.78 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.78 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.78 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.78 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.78 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.78 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.78 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.78 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olomoucine SCHEMBL135056 | 0.88 | CDK1 (1.00) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL7099155 | 0.83 | CDK1 (0.74) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL14182620 | 0.82 | CDK1 (0.87) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL29501842 | 0.79 | CDK2 (0.62) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL449140 | 0.79 | CDK2 (0.62) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL13252976 | 0.78 | CDK1 (0.81) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL448408 | 0.76 | CDK2 (0.58) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL450530 | 0.75 | CDK1 (0.57) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL29501930 | 0.75 | CDK1 (0.57) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL1216905 | 0.74 | CDK1 (1.00) | CDK1CDK2CCNB2CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030186999-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.) | 2003-10-02 | — | — | US | claimed |
| US-20020049218-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIGUE (C.N.R.S.) | 2002-04-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186999-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | PNP, TYMP, NUDT1 | CDK1 501/4885CDK2 359/4885CCNB2 456/4885 |
| US-20020049218-A1 | Purine derivatives having, in particular, antiproliferative properties, and their biological uses | PNP, TYMP, NUDT1 | CDK1 501/4885CDK2 359/4885CCNB2 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.