Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128957 | 0.96 | CHRM4 (0.48) | CHRM4ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7172475 | 0.94 | ALDH1A1 (0.51) | CHRM4ALDH1A1MAPTLMNAPDE5A | |
| SCHEMBL5808078 | 0.90 | CHRM4 (0.45) | CHRM4ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL5113865 | 0.90 | ALDH1A1 (0.54) | CHRM4ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL5119073 | 0.88 | CHRM4 (0.48) | CHRM4ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL5129562 | 0.86 | SMN1; SMN2 (0.47) | CHRM4ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7176321 | 0.84 | CHRM4 (0.44) | CHRM4ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7175621 | 0.83 | GAA (0.47) | ALDH1A1LMNASMN1; SMN2KMT2AGAA | |
| SCHEMBL6944700 | 0.82 | PDE5A (0.51) | ALDH1A1MAPTLMNAHPGDPDE5A | |
| SCHEMBL7171883 | 0.82 | MAPT (0.58) | CHRM4ALDH1A1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-B1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |