Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 19/20 | 0.73 |
| ▸ | DRD3 | P35462 | 15/20 | 0.73 |
| ▸ | DRD4 | P21917 | 7/20 | 0.73 |
| ▸ | DRD2 | P14416 | 14/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10440077 | 0.86 | OPRM1 (0.73) | OPRM1DRD3DRD4DRD2MEN1 | |
| SCHEMBL20245629 | 0.84 | OPRM1 (0.71) | OPRM1DRD3DRD4DRD2MEN1 | |
| SCHEMBL6016876 | 0.81 | OPRM1 (0.67) | OPRM1DRD3DRD4DRD2MEN1 | |
| SCHEMBL12216191 | 0.81 | OPRM1 (0.67) | OPRM1DRD3DRD4DRD2MEN1 | |
| SCHEMBL5038143 | 0.80 | OPRM1 (0.65) | OPRM1DRD3DRD4DRD2MEN1 | |
| Hydrochloric Acid SCHEMBL27553852 | 0.80 | OPRM1 (0.65) | OPRM1DRD3DRD4DRD2MEN1 | |
| SCHEMBL6309263 | 0.80 | OPRM1 (0.65) | OPRM1DRD3DRD4DRD2MEN1 | |
| SCHEMBL10884718 | 0.80 | OPRM1 (0.65) | OPRM1DRD3DRD4DRD2MEN1 | |
| SCHEMBL4399206 | 0.79 | CYP1A2 (0.45) | OPRM1DRD3DRD4DRD2LMNA | |
| SCHEMBL9780534 | 0.78 | OPRM1 (0.67) | OPRM1DRD3DRD4DRD2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187206-A1 | DUAL-TARGET MU OPIOID AND DOPAMINE D3 RECEPTORS LIGANDS; PREPARATION AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-09-09 | — | — | WO | disclosed |
| US-6573282-B1 | Compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors | ADOLOR CORPORATION | 2003-06-03 | — | — | US | disclosed |
| US-5994372-A | ANTIDIARRHEA COMPOUND | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0852494-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-07-15 | — | — | EP | disclosed |
| WO-1997009973-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-03-20 | — | — | WO | disclosed |