Sugi Predict

Sugi Predict / Compounds / SCHEMBL7175185

SCHEMBL7175185

SCHEMBL7175185

COc1cc(C)cc(OC)c1C(=O)P(=O)(C(=O)c1c(C)cccc1Cl)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CHRNA7 P36544 1/20 0.39
▸ PTGS2 P35354 2/20 0.39
▸ ABL1 P00519 1/20 0.39
▸ SRC P12931 1/20 0.39
▸ TRPM4 Q8TD43 1/20 0.38
▸ CXCL12 P48061 1/20 0.38
▸ POLB P06746 3/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ TYK2 P29597 1/20 0.36
▸ GRM4 Q14833 3/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ HDAC6 Q9UBN7 1/20 0.36
▸ TOP1 P11387 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7177647 0.94 PTGS2 (0.41) PTGS2CXCL12POLBMEN1KMT2A
SCHEMBL7180575 0.92 ABCG2 (0.42) CHRNA7PTGS2ABL1SRCTRPM4
SCHEMBL7185417 0.92 CA12 (0.41) CHRNA7PTGS2POLBMEN1KMT2A
SCHEMBL7182187 0.91 CA12 (0.43) CHRNA7PTGS2ABL1SRCTRPM4
SCHEMBL7188204 0.91 TOP1 (0.39) PTGS2POLBMEN1KMT2AMAPT
SCHEMBL7175574 0.89 CA12 (0.43) CHRNA7PTGS2ABL1SRCTRPM4
SCHEMBL7175665 0.86 CA12 (0.43) CHRNA7PTGS2ABL1SRCTRPM4
SCHEMBL7182411 0.86 KMT2A (0.40) ABL1SRCTRPM4MEN1KMT2A
SCHEMBL7180679 0.86 CA12 (0.47) MEN1KMT2AGAAMAPTRAB9A
SCHEMBL7182407 0.86 CA12 (0.40) CHRNA7PTGS2CXCL12POLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1200943-C Organometallic acyl-aryl phosphine CIBA SC HOLDING AG (CH) 2005-05-11 — — CN disclosed
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed
CN-1308081-A Organometallic acyl-aryl phosphine CIBA SC HOLDING AG (CH) 2001-08-15 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 CHRNA7 3184/4885PTGS2 3909/4885ABL1 871/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 CHRNA7 3492/4885PTGS2 3871/4885ABL1 1089/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.