Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTR1E | P28566 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 2/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | GGPS1 | O95749 | 4/20 | 0.31 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375461 | 1.00 | MAPT (0.37) | MAPTALDH1A1LMNAHTR1ES1PR3 | |
| SCHEMBL5377529 | 0.88 | MEN1 (0.39) | MAPTALDH1A1LMNATSHRFGFR1 | |
| SCHEMBL5380102 | 0.88 | FGFR1 (0.34) | MAPTALDH1A1LMNAFGFR1DDR2 | |
| SCHEMBL5398147 | 0.87 | FGFR1 (0.35) | MAPTALDH1A1FGFR1DDR2HPGD | |
| SCHEMBL14554188 | 0.87 | MAP4K4 (0.36) | MAPTALDH1A1LMNAFGFR1DDR2 | |
| SCHEMBL5391965 | 0.86 | FGFR1 (0.36) | MAPTFGFR1DDR2MCL1DGAT2 | |
| SCHEMBL5397809 | 0.86 | PTPN1 (0.36) | MAPTALDH1A1LMNATSHRFGFR1 | |
| SCHEMBL5377561 | 0.85 | FGFR1 (0.34) | MAPTALDH1A1TSHRFGFR1DDR2 | |
| SCHEMBL5373247 | 0.85 | ECE1 (0.38) | MAPTALDH1A1LMNAFGFR1DDR2 | |
| SCHEMBL5382293 | 0.84 | FGFR1 (0.35) | FGFR1DDR2MCL1DGAT2CPT1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313711-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010137-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |