Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | CPT1A | P50416 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5397809 | 0.93 | PTPN1 (0.36) | MAP4K4RXRARXRBRXRGFGFR1 | |
| SCHEMBL5386995 | 0.93 | MAPT (0.38) | MAP4K4RXRARXRBRXRGFGFR1 | |
| SCHEMBL5383426 | 0.92 | MAP4K4 (0.38) | MAP4K4FGFR1DDR2NPC1ALDH1A1 | |
| SCHEMBL5373247 | 0.92 | ECE1 (0.38) | MAP4K4RXRARXRBRXRGFGFR1 | |
| SCHEMBL5391965 | 0.92 | FGFR1 (0.36) | MAP4K4RXRARXRBRXRGFGFR1 | |
| SCHEMBL5380244 | 0.92 | MMP2 (0.36) | MAP4K4RXRARXRBRXRGFGFR1 | |
| SCHEMBL5380109 | 0.92 | L3MBTL1 (0.39) | MAP4K4RXRARXRBRXRGFGFR1 | |
| SCHEMBL5372575 | 0.92 | MAP4K4 (0.38) | MAP4K4RXRARXRBRXRGFGFR1 | |
| SCHEMBL5378724 | 0.91 | SMN1; SMN2 (0.39) | MAP4K4FGFR1DDR2MCL1MAPT | |
| SCHEMBL5377561 | 0.90 | FGFR1 (0.34) | MAP4K4RXRARXRBRXRGFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130011923-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-10 | — | — | US | disclosed |