Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698550 | 1.00 | CYP19A1 (0.58) | CYP19A1CYP11B2AKR1C1CYP1A2CYP2D6 | |
| SCHEMBL6076208 | 1.00 | CYP19A1 (0.58) | CYP19A1CYP11B2AKR1C1CYP1A2CYP2D6 | |
| SCHEMBL7176266 | 1.00 | CYP19A1 (0.58) | CYP19A1CYP11B2AKR1C1CYP1A2CYP2D6 | |
| SCHEMBL5698547 | 1.00 | CYP19A1 (0.58) | CYP19A1CYP11B2AKR1C1CYP1A2CYP2D6 | |
| SCHEMBL5253679 | 0.93 | AKR1C1 (0.55) | CYP19A1CYP11B2AKR1C1CYP1A2CYP2D6 | |
| SCHEMBL5253681 | 0.93 | AKR1C1 (0.55) | CYP19A1CYP11B2AKR1C1CYP1A2CYP2D6 | |
| SCHEMBL6172379 | 0.87 | AKR1C1 (0.70) | AKR1C1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7992874 | 0.87 | AKR1C1 (0.70) | AKR1C1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5183481 | 0.87 | AKR1C1 (0.70) | AKR1C1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5698641 | 0.84 | CYP19A1 (0.59) | CYP19A1CYP11B2AKR1C1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579873-B2 | Treatment of inflammation, arthritis, bone disorders, respiratory system disorders | PHARMACIA CORPORATION | 2003-06-17 | — | — | US | disclosed |