Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992874 | 1.00 | AKR1C1 (0.70) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL5183481 | 1.00 | AKR1C1 (0.70) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6168727 | 0.89 | AKR1C1 (0.56) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6168722 | 0.89 | AKR1C1 (0.56) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6169411 | 0.87 | ALDH1A1 (0.55) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL11079768 | 0.87 | HTT (0.55) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6170117 | 0.87 | MEN1 (0.62) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL5253681 | 0.87 | AKR1C1 (0.55) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6170114 | 0.87 | MEN1 (0.62) | AKR1C1MAPTHPGDMEN1KMT2A | |
| SCHEMBL5253679 | 0.87 | AKR1C1 (0.55) | AKR1C1MAPTHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-60244595-A | — | — | None | — | — | JP | disclosed |
| US-20230271998-A1 | SOLID SUPPORT FOR SYNTHESIZING NUCLEIC ACID SEQUENCES AND METHODS FOR MAKING AND USING | UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-08-31 | — | — | US | disclosed |
| EP-2641910-B1 | CHIRAL SPIRO-PYRIDYLAMIDOPHOSPHINE LIGAND COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF | ZHEJIANG JIUZHOU PHARMA SCIENCE & TECH CO LTD (CN) | 2017-06-28 | — | — | EP | disclosed |
| US-8962839-B2 | Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof | ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2015-02-24 | — | — | US | disclosed |
| US-8962839-B2 | Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof | ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2015-02-24 | — | — | US | disclosed |
| EP-2641910-A1 | CHIRAL SPIRO-PYRIDYLAMIDOPHOSPHINE LIGAND COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF | Zhejiang Jiuzhou Pharma Science & Technology Co., Ltd. (CN) | 2013-09-25 | — | — | EP | disclosed |
| US-20130225822-A1 | CHIRAL SPIRO-PYRIDYLAMIDOPHOSPHINE LIGAND COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF | ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2013-08-29 | — | — | US | disclosed |
| US-20130225822-A1 | CHIRAL SPIRO-PYRIDYLAMIDOPHOSPHINE LIGAND COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF | ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2013-08-29 | — | — | US | disclosed |
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5985902-A | TREATING INFLAMMATION AND INFLAMMATION-ASSOCIATED DISORDERS, SUCH AS ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5633272-A | Substituted isoxazoles for the treatment of inflammation | PHARMACIA & UPJOHN COMPANY LLC | 1997-05-27 | — | — | US | disclosed |
| JP-S60244595-A | THERMAL RECORDING MATERIAL | RICOH CO LTD | 1985-12-04 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225822-A1 | CHIRAL SPIRO-PYRIDYLAMIDOPHOSPHINE LIGAND COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF | WEE1, WEE2, NOTUM | AKR1C1 861/4885MAPT 4720/4885HPGD 1030/4885 |
| US-20230271998-A1 | SOLID SUPPORT FOR SYNTHESIZING NUCLEIC ACID SEQUENCES AND METHODS FOR MAKING AND USING | RNGTT, NSUN2, POLN | AKR1C1 4237/4885MAPT 4759/4885HPGD 2953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.