Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7176460 | 0.97 | GRM5 (0.35) | GRM5CYP1A2KCNH2TOP2AHTR2A | |
| Hydrochloric Acid SCHEMBL7178255 | 0.97 | GRM5 (0.35) | GRM5CYP1A2KCNH2TOP2AHTR2A | |
| Hydrochloric Acid SCHEMBL7179296 | 0.97 | GRM5 (0.35) | GRM5CYP1A2KCNH2TOP2AHTR2A | |
| Hydrochloric Acid SCHEMBL7178930 | 0.97 | GRM5 (0.35) | GRM5CYP1A2KCNH2TOP2AHTR2A | |
| Hydrochloric Acid SCHEMBL7172115 | 0.97 | GRM5 (0.35) | GRM5CYP1A2KCNH2TOP2AHTR2A | |
| Hydrochloric Acid SCHEMBL7171425 | 0.91 | KCNH2 (0.37) | KCNH2KDM4ELMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7173142 | 0.88 | GRIN2D (0.32) | CYP1A2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL7181934 | 0.88 | GRM5 (0.35) | GRM5CYP1A2HTR2AELANEHTT | |
| Hydrochloric Acid SCHEMBL7180525 | 0.88 | CYP1A2 (0.33) | GRM5CYP1A2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL7172221 | 0.88 | KCNH2 (0.37) | KCNH2KDM4ELMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |