Glutamine

Glutamine

SCHEMBL7176754

NC(=O)CC[C@H](N)C(=O)O.O=C(O)C(=O)O

nearest known ligand 0.91

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1SLC6A4

The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.91
ALOX15 P16050 1/20 0.91
BLM P54132 1/20 0.91
PMP22 Q01453 1/20 0.91
GSR P00390 2/20 0.62
CYP1A2 P05177 2/20 0.62
GRM8 O00222 2/20 0.62
GRM6 O15303 2/20 0.62
GRM7 Q14831 2/20 0.62
GRM4 Q14833 2/20 0.62
GRIN2D O15399 1/20 0.62
GRIN3B O60391 1/20 0.62
GRIK1 P39086 1/20 0.62
GRM5 P41594 1/20 0.62
GRIA1 P42261 1/20 0.62
GRIA2 P42262 1/20 0.62
GRIA3 P42263 1/20 0.62
SLC1A3 P43003 1/20 0.62
SLC1A2 P43004 1/20 0.62
SLC1A1 P43005 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glutamine SCHEMBL7176752 1.00 KMT2A (0.91) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL7453 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL994966 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL7452 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL411588 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL411575 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL5580393 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL411170 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL1332116 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR
Glutamine SCHEMBL711605 0.95 KMT2A (1.00) KMT2AALOX15BLMPMP22GSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230307094-A1 METHOD FOR PREDICTING CANCER PROGNOSIS AND MODEL THEREFOR NATIONAL CHENG KUNG UNIVERSITY (TW) 2023-09-28 US disclosed
EP-4224479-A1 METHOD FOR PREDICTING CANCER PROGNOSIS AND MODEL THEREFOR National Cheng Kung University Hospital (TW) 2023-08-09 EP disclosed
EP-0754192-B1 CIRCULARLY PERMUTED LIGANDS AND CIRCULARLY PERMUTED CHIMERIC MOLECULES US GOV HEALTH & HUMAN SERV (US) 2003-01-29 EP disclosed
US-6011002-A NOVEL MODIFIED FORMS OF LIGANDS SUCH AS INTERLEUKIN 4 (IL4) WHEREIN THE AMINO AND CARBOXY ENDS ARE JOINED TOGETHER THROUGH A LINKER, AND NEW AMINO AND CARBOXY TERMINAL ENDS ARE FORMED. MODIFIED LIGANDS ARE AS FULLY ACTIVE AS THE ORIGINAL LIGANDS. THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-01-04 US disclosed
EP-0754192-A1 CIRCULARLY PERMUTED LIGANDS AND CIRCULARLY PERMUTED CHIMERIC MOLECULES THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services (US) 1997-01-22 EP disclosed
WO-1995027732-A2 CIRCULARLY PERMUTED LIGANDS AND CIRCULARLY PERMUTED CHIMERIC MOLECULES THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1995-10-19 WO disclosed