Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180134

SCHEMBL7180134

SCHEMBL7180134

Cc1cccc(C)c1C(=O)P(=O)(C(=O)c1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FABP3 P05413 1/20 0.36
▸ FABP4 P15090 1/20 0.36
▸ L3MBTL1 Q9Y468 2/20 0.35
▸ TYK2 P29597 1/20 0.35
▸ TRPM4 Q8TD43 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ ITGB1 P05556 2/20 0.33
▸ ITGA4 P13612 2/20 0.33
▸ POLB P06746 2/20 0.33
▸ CA2 P00918 1/20 0.33
▸ CA4 P22748 1/20 0.33
▸ CA5A P35218 1/20 0.33
▸ ITGA2 P17301 1/20 0.33
▸ ITGB7 P26010 1/20 0.33
▸ GPR52 Q9Y2T5 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182628 0.93 TYK2 (0.42) FABP3FABP4TYK2TRPM4MAPT
SCHEMBL246249 0.90 L3MBTL1 (0.41) L3MBTL1TDP1POLBCA2CA4
SCHEMBL7182180 0.90 FABP3 (0.36) FABP3FABP4L3MBTL1TYK2TRPM4
SCHEMBL7186634 0.88 KMT2A (0.37) MAPTSMN1; SMN2ALDH1A1MEN1NPC1
SCHEMBL7182453 0.88 TYK2 (0.44) FABP3FABP4TYK2TRPM4MAPT
SCHEMBL7174811 0.88 TYK2 (0.44) FABP3FABP4TYK2TRPM4MAPT
SCHEMBL7184115 0.87 TYK2 (0.39) FABP3FABP4L3MBTL1TYK2TRPM4
SCHEMBL7186494 0.85 TYK2 (0.38) FABP3FABP4TYK2TRPM4MAPT
SCHEMBL7179862 0.84 TYK2 (0.44) FABP3FABP4TYK2TRPM4MAPT
SCHEMBL7180494 0.84 TYK2 (0.40) FABP3FABP4TYK2TRPM4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 FABP3 3252/4885FABP4 4550/4885L3MBTL1 302/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 FABP3 2807/4885FABP4 4256/4885L3MBTL1 126/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.