Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11139466 | 0.98 | HDAC8 (0.56) | HDAC8HDAC6EPHX1SMN1; SMN2HSD17B10 | |
| SCHEMBL11031178 | 0.83 | HDAC8 (0.56) | HDAC8HDAC6EPHX1SMN1; SMN2HSD17B10 | |
| SCHEMBL7695741 | 0.81 | HDAC8 (0.48) | HDAC8HDAC6EPHX1SMN1; SMN2HSD17B10 | |
| SCHEMBL15082184 | 0.81 | HDAC8 (0.48) | HDAC8HDAC6EPHX1SMN1; SMN2HSD17B10 | |
| SCHEMBL19060 | 0.79 | HDAC8 (0.52) | HDAC8HDAC6EPHX1SMN1; SMN2HSD17B10 | |
| SCHEMBL22169725 | 0.78 | HDAC8 (0.50) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL15931748 | 0.76 | HDAC8 (0.43) | HDAC8HDAC6EPHX1SMN1; SMN2HSD17B10 | |
| SCHEMBL22169769 | 0.76 | HDAC8 (0.48) | HDAC8HDAC6EPHX1SMN1; SMN2CES2 | |
| SCHEMBL22503052 | 0.76 | HDAC8 (0.43) | HDAC8HDAC6EPHX1SMN1; SMN2HSD17B10 | |
| SCHEMBL29633560 | 0.76 | HDAC8 (0.43) | HDAC8HDAC6EPHX1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583130-B1 | Substituted with acyl, oxycarbonyl, aminocarbonyl, sulfonyl, or aminosulfonyl; inhibit steroid sulfatase, do not exhibit any estrogenic effect and will not yield any estrogenic products on hydrolysis; treatment of estrogen-dependent tumors | SCHERING AG (DE) | 2003-06-24 | — | — | US | claimed |
| US-6583130-B1 | Substituted with acyl, oxycarbonyl, aminocarbonyl, sulfonyl, or aminosulfonyl; inhibit steroid sulfatase, do not exhibit any estrogenic effect and will not yield any estrogenic products on hydrolysis; treatment of estrogen-dependent tumors | SCHERING AG (DE) | 2003-06-24 | — | — | US | disclosed |