Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7180590 | 0.92 | ITGA4 (0.59) | ITGA4GAAHPGDITGB1ITGA5 | |
| SCHEMBL7327448 | 0.86 | ITGA4 (0.54) | ITGA4RAB9AGAAHPGDITGB1 | |
| SCHEMBL3849601 | 0.85 | ITGA4 (0.60) | ITGA4RAB9AGAAHPGDITGB1 | |
| SCHEMBL6712426 | 0.85 | ITGA4 (0.59) | ITGA4RAB9AGAAHPGDITGB1 | |
| SCHEMBL6709486 | 0.85 | ITGA4 (0.59) | ITGA4RAB9AGAAHPGDITGB1 | |
| SCHEMBL5690332 | 0.85 | ITGA4 (0.59) | ITGA4RAB9AGAAHPGDITGB1 | |
| SCHEMBL6709270 | 0.84 | ITGA4 (0.60) | ITGA4RAB9AGAAHPGDITGB1 | |
| SCHEMBL5690625 | 0.84 | MAPK1 (0.66) | ITGA4GAAITGB1ITGA5TSHR | |
| SCHEMBL6710835 | 0.84 | ITGA4 (0.55) | ITGA4RAB9AITGB1ITGA5TSHR | |
| SCHEMBL3850808 | 0.84 | ITGA4 (0.55) | ITGA4RAB9AGAAHPGDITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583139-B1 | Treatment of inflammatory diseases; inflammatory brain diseases such as multiple sclerosis; N-(Toluene-4-sulfonyl)-L-prolyl-4-(alpha -methylbenzyloxy)-L-phenylalanine; Very Late Antigen 4 | BIOGEN IDEC INTERNATIONAL HOLDING LTD. (BM) | 2003-06-24 | — | — | US | disclosed |