Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180872

SCHEMBL7180872

SCHEMBL7180872

COc1cc(OC)c(C(=O)P(=O)(C(=O)c2c(Cl)ccc(C)c2Cl)c2ccccc2)c(OC)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCG2 Q9UNQ0 2/20 0.39
▸ KMT2A Q03164 6/20 0.38
▸ POLB P06746 6/20 0.38
▸ MEN1 O00255 5/20 0.38
▸ MAPT P10636 4/20 0.37
▸ GRM4 Q14833 2/20 0.37
▸ ATM Q13315 2/20 0.37
▸ CYP3A4 P08684 2/20 0.37
▸ TP53 P04637 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ HDAC6 Q9UBN7 1/20 0.37
▸ TSHR P16473 1/20 0.36
▸ NPC1 O15118 3/20 0.36
▸ RAB9A P51151 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ KCNH2 Q12809 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180921 0.92 ABCG2 (0.41) ABCG2KMT2APOLBMEN1MAPT
SCHEMBL7184834 0.90 CA12 (0.41) KMT2APOLBMEN1MAPTGRM4
SCHEMBL7180575 0.87 ABCG2 (0.42) ABCG2KMT2APOLBMEN1MAPT
SCHEMBL7175458 0.87 ABCG2 (0.46) ABCG2KMT2APOLBMEN1MAPT
SCHEMBL7183286 0.86 ALDH1A1 (0.47) ABCG2KMT2APOLBMEN1MAPT
SCHEMBL7180078 0.86 CA12 (0.40) KMT2APOLBMEN1GRM4ATM
SCHEMBL7178118 0.86 ABCG2 (0.42) ABCG2KMT2APOLBMEN1MAPT
SCHEMBL7182500 0.86 KMT2A (0.41) ABCG2KMT2APOLBMEN1MAPT
SCHEMBL2768729 0.85 KMT2A (0.47) ABCG2KMT2AMEN1MAPTATM
SCHEMBL7175981 0.85 ABCG2 (0.44) ABCG2KMT2APOLBMAPTATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ABCG2 3732/4885KMT2A 1586/4885POLB 2322/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ABCG2 4323/4885KMT2A 956/4885POLB 2993/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.