Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180989

SCHEMBL7180989

SCHEMBL7180989

COc1ccc(C(=O)c2ccccc2[P](=O)C(=O)c2c(C)cc(C)c(C)c2C)c(OC)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 8/20 0.45
▸ LMNA P02545 5/20 0.41
▸ HPGD P15428 4/20 0.41
▸ CYP1A2 P05177 2/20 0.41
▸ CYP3A4 P08684 2/20 0.41
▸ CYP2C19 P33261 2/20 0.41
▸ PGR P06401 1/20 0.41
▸ ADORA3 P0DMS8 1/20 0.41
▸ AR P10275 1/20 0.41
▸ CHRM1 P11229 1/20 0.41
▸ ALOX15 P16050 1/20 0.41
▸ TBXA2R P21731 1/20 0.41
▸ SLC6A2 P23975 1/20 0.41
▸ ADRA1A P35348 1/20 0.41
▸ HIF1A Q16665 1/20 0.41
▸ ALDH1A1 P00352 4/20 0.41
▸ MEN1 O00255 3/20 0.40
▸ KMT2A Q03164 3/20 0.40
▸ TSHR P16473 1/20 0.40
▸ RAB9A P51151 8/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7187667 0.89 ALDH1A1 (0.38) NPC1LMNAHPGDCYP1A2CYP3A4
SCHEMBL7175690 0.89 NPC1 (0.47) NPC1LMNAHPGDCYP1A2CYP3A4
SCHEMBL7188264 0.88 NPC1 (0.48) NPC1LMNAHPGDCYP1A2CYP3A4
SCHEMBL7185356 0.87 ALDH1A1 (0.38) NPC1LMNAHPGDCYP1A2CYP3A4
SCHEMBL7187919 0.86 NPC1 (0.51) NPC1LMNAHPGDCYP1A2CYP3A4
SCHEMBL7177189 0.85 NPC1 (0.50) NPC1LMNAHPGDCYP1A2CYP3A4
SCHEMBL7181666 0.83 KCNK3 (0.37) NPC1ALDH1A1MEN1KMT2ARAB9A
SCHEMBL7189615 0.83 PTPN1 (0.33) NPC1LMNAHPGDCYP3A4ALDH1A1
SCHEMBL7181631 0.82 ALDH1A1 (0.33) LMNAHPGDCYP3A4ALDH1A1MEN1
SCHEMBL7183314 0.82 ABCG2 (0.48) NPC1LMNAHPGDCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 NPC1 772/4885LMNA 3241/4885HPGD 3983/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 NPC1 872/4885LMNA 3247/4885HPGD 4041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.