Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | DGKA | P23743 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | POLA1 | P09884 | 1/20 | 0.46 |
| ▸ | PAM | P19021 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 3/20 | 0.43 |
| ▸ | CES1 | P23141 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27700699 | 0.83 | DGKA (0.52) | TSHRCNR2DGKALMNAPOLB | |
| SCHEMBL27482958 | 0.83 | DGKA (0.52) | TSHRCNR2DGKALMNAPOLB | |
| SCHEMBL991447 | 0.81 | CNR2 (0.49) | TSHRCNR2DGKALMNAPOLB | |
| SCHEMBL27630679 | 0.79 | TSHR (0.53) | TSHRCNR2DGKAFAAHLMNA | |
| SCHEMBL28328608 | 0.79 | TSHR (0.53) | TSHRCNR2DGKAFAAHLMNA | |
| SCHEMBL22129994 | 0.79 | TSHR (0.53) | TSHRCNR2DGKAFAAHLMNA | |
| SCHEMBL1018382 | 0.79 | TSHR (0.53) | TSHRCNR2DGKAFAAHLMNA | |
| SCHEMBL20699246 | 0.79 | TSHR (0.53) | TSHRCNR2DGKAFAAHLMNA | |
| SCHEMBL27868024 | 0.79 | TSHR (0.53) | TSHRCNR2DGKAFAAHLMNA | |
| SCHEMBL2399372 | 0.77 | TSHR (0.51) | TSHRCNR2DGKAFAAHLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559209-B1 | Method of making a rubber composition which is improved in a dispersibility of silica into rubber, a heat generating property and an abrasion property. The rubber composition comprises 15 to 85 parts by weight of silica per 100 parts of | BRIDGESTONE CORPORATION (JP) | 2003-05-06 | — | — | US | disclosed |
| EP-0846724-A2 | RUBBER COMPOSITION AND PNEUMATIC TIRE | Bridgestone Corporation (JP) | 1998-06-10 | — | — | EP | disclosed |